Recovery and assessment timescales in cirrhosis extend from weeks to months. Initial post-infusion inflammatory responses subside within 1–2 weeks. Changes in liver synthetic function (albumin, bilirubin, INR) are typically measured at 2, 4, 8, and 12 weeks post-infusion to assess response. Hepatic imaging (ultrasound, transient elastography) may be repeated at 3 and 6 months to evaluate fibrosis progression. Clinical improvement in ascites, encephalopathy, or variceal bleeding risk may become apparent over 2–4 weeks but often requires months to solidify. Importantly, cirrhosis does not 'recover' in the traditional sense; the goal is stabilisation and slowed deterioration, not functional restoration.
Cirrhosis trials represent the most mature evidence base among stem-cell-investigated liver diseases. Published studies have documented improvements in liver synthetic function (albumin, prothrombin time), reductions in portal hypertension parameters, and enhanced hepatic blood flow following MSC infusion. Several trials reported reduced variceal bleeding incidence and slower progression to hepatic encephalopathy. However, many studies remain observational and uncontrolled; head-to-head comparisons with standard care (diuretics, beta-blockers, endoscopic banding) are sparse. Disease heterogeneity — varying aetiology (viral hepatitis, alcohol, autoimmune) and cirrhosis stage — limits generalisation of results. Long-term transplant-free survival data are limited; many patients eventually require liver transplantation despite MSC treatment.
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由 StemCellAtlas 的编辑团队进行医学审查，与Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) 合作诊所 Stem Plus（索菲亚）的，根据 ISSCR、FDA 和 EMA 指南。 Educational information, not medical advice; figures indicative.
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