Immediate post-operative recovery (wound healing, neurogenic shock stabilisation) spans 2–4 weeks; infection risk is highest in the first 6 weeks and requires vigilant monitoring. Neurological recovery begins at 4+ weeks; functional testing (ASIA examination, manual muscle testing) establishes baselines at 8–12 weeks. Intensive rehabilitation (5–7 days/week) is critical during months 2–6 and typically continues for 12 months. Most patients require inpatient or day-care rehabilitation programmes.
Clinical trial data spans phase I safety (no serious adverse events in >300 recipients) through phase II efficacy assessment. Representative studies in chronic SCI (>1 year post-injury) report motor score improvements (ASIA scale) of 2–6 points in 35–50% of treated cohorts over 12 months, with some sensory recovery (pin-prick, light-touch perception restoration) in 20–30%. Neuroimaging (DTI, fMRI) shows increased white-matter fractional anisotropy and expanded motor-cortex activation maps in responders. Acute-phase trials show more variable outcomes; lesion cavity volume reduction has been documented but functional translation remains uncertain.
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由 StemCellAtlas 的编辑团队进行医学审查，与Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) 合作诊所 Stem Plus（索菲亚）的，根据 ISSCR、FDA 和 EMA 指南。 Educational information, not medical advice; figures indicative.
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