Duration of benefit from MSC infusion in rheumatoid arthritis typically spans 6–12 months when disease-modifying drugs are concurrently maintained. Without conventional immunosuppression, relapse occurs more frequently, often within 3–9 months. Some centres propose booster infusions at 6–12 month intervals; limited long-term data exist on safety and efficacy of repeated cycles. Immune tolerance to the transplanted MSCs may wane over time, explaining declining durability. The underlying autoimmune disease biology means that MSC benefit, even if sustained, does not cure the condition; ongoing disease control requires either repeated MSC infusions or concurrent conventional therapy.
Rheumatoid arthritis is a chronic autoimmune condition where the immune system erroneously attacks joint synovium, causing inflammation, cartilage degradation, and bone erosion. Stem-cell investigations, primarily using placental mesenchymal stem cells, explore whether these cells can modulate the underlying immune dysregulation and reduce synovial inflammation. MSCs secrete immunosuppressive cytokines and may shift macrophage polarisation from pro-inflammatory (M1) to anti-inflammatory (M2) phenotypes. With 43 registered trials and 7 currently recruiting, the therapeutic premise differs from muscular dystrophy: rather than direct tissue regeneration, MSCs aim to suppress the aberrant T-cell and B-cell responses driving the disease. Early clinical data suggest potential for joint-specific injection or systemic administration to reduce disease activity scores and inflammation markers.
האם אני מועמד? → · Rheumatoid Arthritis: full overview → · עלות דלקת פרקים ראומטואידית → · Cost →
בדוקה רפואית על ידי צוות העריכה של StemCellAtlas עם Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) של קליניקת השותף Stem Plus (סופיה), כנגד הנחיות ISSCR, FDA ו-EMA. Educational information, not medical advice; figures indicative.
רפואה רגנרטיבית מאושרת GMP בלב האיחוד האירופי — החל מ-3,000–8,000 יורו, חלק קטן ממחירי ארהב או גרמניה. פרוטוקולים מותאמים אישית למטופלים מ-50+ מדינות.
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