Current literature describes symptom improvement in roughly 60–75% of trial participants, though definitions of 'improvement' vary widely and placebo response rates in menopausal symptom trials historically exceed 40%. No head-to-head trials against hormone therapy exist. Real-world outcomes beyond trial settings remain unreported. The wide range reflects heterogeneous populations and measurement methods rather than robust efficacy.
Approximately 10 registered trials are investigating stem cell and exosome therapies for menopause-related symptoms. A 2023 small-scale study of placental MSCs reported subjective improvement in hot flush frequency in 70% of participants over 12 weeks, though follow-up assessments remain limited. Exosome trials have focused on anti-inflammatory signalling rather than direct hormone replacement. No large multicentre randomised controlled trials have yet demonstrated safety or efficacy comparable to hormone therapy, and recruitment for new menopause-focused stem cell studies has stalled. Evidence remains preliminary and largely mechanistic.
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Медицинское рецензирование редакторской командой StemCellAtlas с Dr Dmytro Stoyanov (Urologist · 31+ yrs clinical practice) клиники-партнёра Stem Plus (София) в соответствии с руководствами ISSCR, FDA и EMA. Educational information, not medical advice; figures indicative.
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