Pain relief and improved functional scores (reduced limp, easier stair climbing, longer walking tolerance) occur in 60–75% of treated participants within 3–6 months. Radiographic cartilage thickening or preservation of joint space is observed in approximately 40–50% of cases on follow-up imaging. Successful outcomes are more common in early-stage OA (Kellgren-Lawrence grade 2) than in severe disease.
Twelve completed trials and 3 actively recruiting trials are registered for hip osteoarthritis cell therapy, predominantly using placental MSC or chondrocyte injection into the hip joint under fluoroscopic guidance. Trial cohorts span mild-to-moderate radiographic OA (Kellgren-Lawrence grades 2–3) and include both primary OA and post-traumatic arthritis. Cartilage imaging by MRI has shown improved signal intensity (suggesting rehydrated cartilage matrix) in 40–60% of treated hips at 12 months. Pain scores and functional metrics (6-minute walk distance, Harris Hip Score) improve modestly in 55–75% of participants over 6–24 months, though comparative data versus placebo injection are sparse.
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Медицинское рецензирование редакторской командой StemCellAtlas с Dr Tymur Lukyanenko (Orthopaedic Traumatologist · 20+ yrs clinical, 15+ yrs cell therapy) клиники-партнёра Stem Plus (София) в соответствии с руководствами ISSCR, FDA и EMA. Educational information, not medical advice; figures indicative.
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