Intravenous infusion is a brief outpatient procedure (20–45 minutes). Acute side effects (fever, transient joint pain, fatigue flare) may occur in 5–10% of recipients within 48 hours. Symptom assessment requires weeks to months because fibromyalgia itself fluctuates. Many advocates recommend concurrent physiotherapy, cognitive behavioural therapy, or medication adjustment, so isolating the cell-therapy effect is challenging.
Only 1 completed trial and 0 actively recruiting trials are registered specifically for fibromyalgia cell therapy, reflecting the early, exploratory stage of this application. That single published study involved placental MSC infusion in a small cohort (n≈20–30) and reported modest improvements in pain scores (average 20–30% reduction on visual analogue pain scale) and some improvement in fatigue severity. Biochemical markers of inflammation (IL-6, TNF-α) showed trending reductions. No control arm was present, and long-term follow-up was not reported.
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Revizuit medical de echipa editorială a StemCellAtlas cu Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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