The FDA has not approved a stem-cell or exosome therapy specifically for arterial hypertension as a licensed product. Investigational MSC protocols are registered with the NIH but remain unapproved. The EMA likewise has not granted a marketed hypertension-specific stem-cell therapy. Established antihypertensive drug classes (ACE inhibitors, ARBs, calcium-channel blockers, diuretics) remain the FDA gold standard and evidence-based first-line treatment. Any marketed stem-cell therapy for hypertension should be scrutinised; unapproved direct-to-consumer claims abound in this prevalent condition.
Arterial hypertension, or high blood pressure, arises from dysregulated vascular tone, altered endothelial function, sympathetic overactivity, and rarefaction of capillary beds — pathophysiological mechanisms studied across essential and secondary forms. Stem-cell research investigates whether placental mesenchymal stem cells and exosome preparations can restore endothelial homeostasis, promote vascular regeneration, suppress renin-angiotensin-aldosterone axis overactivity, and enhance nitric-oxide bioavailability. With 35 registered trials and 4 currently recruiting, the therapeutic rationale targets restoration of vascular biology rather than symptomatic blood-pressure control. Early clinical data suggest potential for reducing office and ambulatory blood pressure, improving microvascular function, and reducing left-ventricular hypertrophy when administered as adjuncts to standard antihypertensive therapy.
Sunt un candidat? → · Arterial Hypertension: full overview → · Cost Hipertensiune Arterială → · Cost →
Revizuit medical de echipa editorială a StemCellAtlas cu Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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