How long does stem cell therapy for Premature Ovarian Insufficiency last?
There is insufficient controlled evidence to establish restored ovarian function or its duration, and repeat treatment is not a standard. POI may include intermittent ovarian activity, so menstruation or hormone change after a procedure does not prove a durable treatment effect. Long-term reproductive and safety follow-up is required.
How stem cells are studied for Premature Ovarian Insufficiency
Premature ovarian insufficiency (POI) is loss of ovarian function before age 40, confirmed through menstrual history and biochemical assessment. It can affect fertility, bone, cardiovascular, sexual and psychological health. Causes and residual ovarian activity vary. Mesenchymal stromal cells (MSCs) and other biological approaches are being studied, but proposed follicle, hormonal or immune mechanisms have not established restored fertility or live birth. Cell injection or infusion is not standard POI care. The registry table on this page lists relevant studies and their current recruitment status.
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Evidence checked against ISSCR, FDA and EMA guidance. See our editorial standards. This is information, not medical advice. Educational information, not medical advice; figures indicative.
Sources & further reading
More on this condition
- Premature Ovarian Insufficiency: cell-therapy evidence and registered trials
- How much does stem cell therapy for Premature Ovarian Insufficiency cost? (2026)
- Premature Ovarian Insufficiency stem cell therapy — your questions answered (2026)
- Premature Ovarian Insufficiency: cell-therapy evidence by therapy class
- MSC vs PRP for Premature Ovarian Insufficiency: what the registries show