What is the success rate of stem cell therapy for Premature Ovarian Insufficiency?
There is no reliable success rate for POI cell therapy. Menstrual bleeding, hormone change, follicle visibility, oocyte retrieval, pregnancy and live birth are distinct endpoints. Small series with different products, routes and patient selection cannot predict an individual's reproductive outcome. The registered studies and their own prespecified endpoints are listed in the registry table on this page.
What the evidence shows for Premature Ovarian Insufficiency
POI cell-therapy evidence is early and heterogeneous. Menstruation, hormone levels, ultrasound follicles, oocyte retrieval, pregnancy and live birth are different outcomes and must not be treated as interchangeable. Small uncontrolled series cannot establish that an intervention restored ovarian function or caused a pregnancy. No pooled response rate is published here because product, route, patient selection and endpoints differ too widely. The registered studies and their own prespecified endpoints are listed in the registry table on this page.
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Evidence checked against ISSCR, FDA and EMA guidance. See our editorial standards. This is information, not medical advice. Educational information, not medical advice; figures indicative.
Sources & further reading
More on this condition
- Premature Ovarian Insufficiency: cell-therapy evidence and registered trials
- How much does stem cell therapy for Premature Ovarian Insufficiency cost? (2026)
- Premature Ovarian Insufficiency stem cell therapy — your questions answered (2026)
- Premature Ovarian Insufficiency: cell-therapy evidence by therapy class
- MSC vs PRP for Premature Ovarian Insufficiency: what the registries show