Duration of restored ovarian function is variable. Some women report sustained menstrual cycles and continued hormone production for 1–3 years post-treatment; others experience recurrent POI and return to amenorrhoea within 6–12 months. Long-term follow-up data are sparse; treatment may need repetition to maintain benefit.
Premature ovarian insufficiency (POI)—formerly called premature ovarian failure—is cessation of ovarian hormone production and egg release before age 40, affecting approximately 1 in 100 women. Causes include genetic mutations (e.g., FMR1), autoimmune attack on follicles, chemotherapy or radiation damage, infection, or idiopathic (unknown) depletion of the primordial follicle pool. The result is infertility, oestrogen deficiency, and systemic menopausal symptoms despite young age. Current treatment is hormone replacement; fertility restoration is limited. Placental MSCs and fetal stem cells are being explored to regenerate follicle development or restore ovarian hormone production through direct cellular replacement, growth-factor secretion, and immunomodulation (suppressing anti-ovarian autoimmunity). Transplantation of cells into the ovary or systemic infusion aims to stimulate dormant follicles or create a regenerative microenvironment.
Съм ли кандидат? → · Premature Ovarian Insufficiency: full overview → · Цена Преждевременна овариална недостатъчност → · Cost →
Медицински преглед от редакционния екип на StemCellAtlas с Dr Dmytro Stoyanov (Urologist · 31+ yrs clinical practice) на партньорската клиника Stem Plus (София), спрямо ISSCR, FDA и EMA указания. Educational information, not medical advice; figures indicative.
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