Placental MSC infusion is a brief outpatient procedure; acute effects resolve within 48 hours. Functional improvement in skin mobility and hand range of motion typically emerges over 4–8 weeks. HSCT involves 4–6 weeks of intensive inpatient care during conditioning and recovery, followed by 6–12 months of restricted activity and close monitoring; full functional recovery takes months.
Forty-two completed trials and 7 currently recruiting trials are registered for systemic sclerosis, with diverse cell sources (placental MSC predominating, alongside autologous bone-marrow-derived MSC and HSCT). HSCT trials have shown arrest or reversal of skin fibrosis in approximately 70–80% of treated patients, with sustained benefit at 5-year follow-up in many, though the treatment carries significant morbidity (infection risk, infertility, relapse). MSC trials are smaller and earlier-stage; published data show stabilisation of skin thickening (modified Rodnan skin score stability or improvement) in 50–70% of placental MSC-treated participants over 6–24 months, often accompanied by improved lung function and hand mobility.
Sunt un candidat? → · Scleroderma (Systemic Sclerosis): full overview → · Cost Scleroderma (Scleroze Sistemică) → · Cost →
Revizuit medical de echipa editorială a StemCellAtlas cu Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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