Recovery and assessment timescales in erectile dysfunction extend from weeks to months. Initial post-infusion penile swelling or discomfort (if local injection used) typically resolves within 1–2 weeks. Meaningful functional improvement usually requires 4–12 weeks to emerge, as neovascularisation and smooth-muscle regeneration proceed. Erectile function is assessed at baseline, 4 weeks, 8 weeks, 12 weeks, and 6 months post-infusion using validated questionnaires (IIEF-5 or IIEF-15) and partner feedback where appropriate. Penile Duplex ultrasound may be repeated at 8–12 weeks to assess vascular response. Patients should not expect immediate rigidity gain; gradual improvement over weeks is the norm. Sexual activity can typically resume 2–4 weeks post-treatment depending on infusion method.
Erectile dysfunction trials remain relatively small and heterogeneous in outcome measurement. Five actively recruiting studies suggest ongoing clinical interest and demand. Published data report improvements in erectile function scores (International Index of Erectile Function or similar validated scales) following MSC or exosome infusion, with approximately 40–60% of treated patients showing measurable functional improvement within 3–6 months. Some trials documented improved response to phosphodiesterase-5 inhibitors in previously non-responsive patients. Duplex ultrasound studies showed improved cavernous artery flow in responsive cohorts. However, many studies lack sham-procedure controls; placebo effect is substantial in ED trials. Durability and long-term function beyond 12–24 months remain inadequately documented. Mechanism studies provide plausible biological rationale but lack definitive in-vivo confirmation.
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Revizuit medical de echipa editorială a StemCellAtlas cu Dr Dmytro Stoyanov (Urologist · 31+ yrs clinical practice) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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