For CKD stage 2–3 patients with active proteinuria or declining function despite optimised conventional therapy, investigational stem-cell treatment may represent a reasonable option given the alternative of progressive decline toward dialysis. Stage 4–5 patients should weigh lower response likelihood against the urgent need for renal replacement planning. Quality-of-life gains (postponing dialysis by 1–3 years) and cost should be weighed alongside trial protocol robustness and centre expertise.
Chronic kidney disease (CKD) reflects progressive nephron loss and functional decline, stemming from diverse primary insults (diabetes, hypertension, glomerulonephritis, polycystic kidney disease). Placental mesenchymal stem cells and their exosomes demonstrate anti-inflammatory and pro-regenerative properties relevant to CKD pathophysiology: they suppress macrophage infiltration into damaged glomeruli, inhibit fibrotic signalling pathways (TGF-β, SMAD2/3), and release growth factors that stabilise endothelial integrity. Eighty-eight registered trials and nine actively recruiting sites explore MSC infusion alongside conventional renin-angiotensin blockade and immunosuppression, particularly in early-to-intermediate stage disease where residual filtration capacity remains.
Sunt un candidat? → · Chronic Kidney Disease: full overview → · Cost Boala Renală Cronică → · Cost →
Revizuit medical de echipa editorială a StemCellAtlas cu Dr Polina Krasenova (Haematologist · Clinical Haematology & Integrative Oncology · 15+ yrs cell therapy) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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