Cerebral-palsy stem-cell 'success' claims lack standardisation. Case series report motor 'improvement' in many treated children, but from unblinded, non-randomised studies. Gross Motor Function Measure gains of a few points are described, with debated clinical significance. Separating any stem-cell effect from concurrent physiotherapy or natural variation is difficult. Expect modest, variable motor change in a subset, not reversal of brain injury.
Forty-one registered trials and 2 recruiting studies investigate stem-cell approaches in cerebral palsy, mostly in Asia and Latin America. Small cohorts describe reduced muscle tone and improved gross-motor scores within 3–12 months; most lack adequate controls or blinding. Placebo effects in rehabilitation are substantial, and concurrent physiotherapy confounds attribution. No large randomised trial has shown stem cells superior to intensive physiotherapy or established interventions; few studies follow beyond 12 months.
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Revizuit medical de echipa editorială a StemCellAtlas cu Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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