No consensus definition of 'success' exists in autism stem-cell trials. Published case reports describe changes in irritability, focus or social initiation in selected children, but these lack objective measurement and controls. Across the 26 registered trials outcomes range widely; some report no measurable change. 'Success-rate' figures in promotional materials are unvalidated and derive from unblinded studies. Treat any high-success claim with scepticism.
Twenty-six registered trials and 6 actively recruiting studies explore stem-cell approaches in autism, primarily small, uncontrolled observational designs. Published reports describe behavioural changes in individual cases, but lack placebo controls, randomisation, or blinded assessment. Most data come from Asia-Pacific clinics; few reach peer-reviewed journals. The theoretical rationale — that placental MSCs reduce neuroinflammation — remains unproven in human brains. No trial has demonstrated meaningful, durable change in core autism features attributable to stem cells alone.
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Revizuit medical de echipa editorială a StemCellAtlas cu Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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