Intravenous infusion needs minimal acute recovery; intracerebral surgery requires 2–4 weeks of reduced activity and neurological monitoring. True motor recovery would require months if cells engraft and differentiate, and is incomplete at best. Patients continue dopaminergic medication during and after. There is no period in which Parkinson's reverses; ongoing management remains necessary.
Sixty-nine registered trials and 16 recruiting studies investigate stem-cell approaches in Parkinson's. Small series document modest motor-symptom changes within 6–12 months, but are typically unblinded, single-arm, and lack sham controls. A few report dopamine-replacement activity on PET imaging; durability beyond 12 months is sparse. Heterogeneous cell products and delivery routes complicate interpretation. No trial has prevented progression or restored motor function to pre-disease levels.
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Revizuit medical de echipa editorială a StemCellAtlas cu Kiian Nadiia, MD, PhD (Paediatric Neurologist · Medical Director, CSM Clinic Network · 12+ yrs in Autism Spectrum Disorders) ale clinicii partenere Stem Plus (Sofia), în funcție de orientările ISSCR, FDA și EMA. Educational information, not medical advice; figures indicative.
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